{"id":1032,"date":"2024-02-25T14:53:53","date_gmt":"2024-02-25T13:53:53","guid":{"rendered":"https:\/\/www.utopiasis.it\/?page_id=1032"},"modified":"2024-03-08T08:00:41","modified_gmt":"2024-03-08T07:00:41","slug":"t-one-therapeutics-srl","status":"publish","type":"page","link":"https:\/\/www.utopiasis.it\/en\/t-one-therapeutics-srl\/","title":{"rendered":"T-One Therapeutics Srl"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”sezione blocco 1″ _builder_version=”4.24.2″ _module_preset=”default” background_color=”gcid-ac150a38-2027-4fd4-8963-25e8b6f6f839″ custom_margin=”85px||||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{%22gcid-ac150a38-2027-4fd4-8963-25e8b6f6f839%22:%91%22background_color%22%93}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” _builder_version=”4.24.2″ _module_preset=”default” width=”100%” max_width=”100%” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.24.2″ _module_preset=”default” background_enable_image=”off” background_video_mp4=”https:\/\/www.utopiasis.it\/wp-content\/uploads\/2024\/03\/iStock-1317698020.mov” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.utopiasis.it\/wp-content\/uploads\/2024\/03\/logo-home.png” title_text=”logo-home” _builder_version=”4.24.2″ _module_preset=”default” background_color=”#FFFFFF” custom_margin=”25%|25%|25%|25%|false|false” custom_padding=”20px|20px|20px|20px|false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.24.2″ _module_preset=”default” custom_padding=”100px|60px|100px|60px|true|true” global_colors_info=”{}”][et_pb_text _builder_version=”4.24.2″ _module_preset=”default” header_2_text_color=”gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14″ header_2_font_size=”30px” custom_margin=”||0px||false|false” locked=”off” global_colors_info=”{%22gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14%22:%91%22header_2_text_color%22%93}”]<\/p>\n

T-One Therapeutics s.r.l.<\/h2>\n

[\/et_pb_text][et_pb_divider color=”gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14″ _builder_version=”4.24.2″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”||||false|false” locked=”off” global_colors_info=”{%22gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14%22:%91%22color%22%93}”][\/et_pb_divider][et_pb_text _builder_version=”4.24.2″ _module_preset=”default” header_4_text_color=”gcid-b7a20a05-ac47-46ee-846a-44540a53bb38″ header_4_line_height=”1.4em” global_colors_info=”{%22gcid-b7a20a05-ac47-46ee-846a-44540a53bb38%22:%91%22header_4_text_color%22%93}”]<\/p>\n

T-ONE THERAPEUTICS SRL: LINE1 TO FIGHT CANCER<\/h4>\n

[\/et_pb_text][et_pb_text _builder_version=”4.24.2″ _module_preset=”default” text_text_color=”#000000″ text_font_size=”17px” text_line_height=”1.8em” text_orientation=”justified” global_colors_info=”{}”]The company is a spin-off of the National Institute of Molecular Genetics “Romeo and Enrica Invernizzi” (INGM).<\/p>\n

The central point of Professor Beatrice Bodega’s discovery, co-founder of T-One Therapeutics, is attributing for the first time a crucial function in regulating the activation of T lymphocytes to certain sequences of human DNA (LINE1), sequences considered genetic waste for years.<\/p>\n

Researchers at INGM instead discovered that these sequences are essential in inhibiting the functionality of T lymphocytes, immune system cells that are the primary pharmacological target for tumor immunotherapy (a therapy that has revolutionized the field of anti-tumor treatments in the last 10 years).[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_6,1_6,1_6″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” _builder_version=”4.24.2″ _module_preset=”default” width=”100%” max_width=”100%” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.24.2″ _module_preset=”default” custom_padding=”100px|60px|100px|60px|true|true” global_colors_info=”{}”][et_pb_text _builder_version=”4.24.2″ _module_preset=”default” text_text_color=”#000000″ text_font_size=”17px” text_line_height=”1.8em” text_orientation=”justified” global_colors_info=”{}”]To degrade LINE1 RNA, the company has identified molecules called ASOs (antisense oligonucleotides).<\/p>\n

The project aims to identify ASO molecules that can reactivate the immune response of “exhausted” T lymphocytes within the tumor microenvironment and thus fight the tumor from within.<\/p>\n

Utopia invested in August 2022.[\/et_pb_text][et_pb_blurb title=”www.tonetx.eu” url=”https:\/\/tonetx.eu\/” url_new_window=”on” use_icon=”on” font_icon=”I||divi||400″ icon_color=”gcid-b7a20a05-ac47-46ee-846a-44540a53bb38″ icon_placement=”left” _builder_version=”4.24.2″ _module_preset=”default” header_font=”||||||||” header_font_size=”17px” custom_margin=”||||false|false” custom_padding=”30px||||false|false” global_colors_info=”{%22gcid-b7a20a05-ac47-46ee-846a-44540a53bb38%22:%91%22icon_color%22%93}”][\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.24.2″ _module_preset=”default” background_color=”gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14″ custom_padding=”20px|20px|20px|20px|true|true” global_colors_info=”{%22gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14%22:%91%22background_color%22%93}”][et_pb_image src=”https:\/\/www.utopiasis.it\/wp-content\/uploads\/2024\/03\/1.png” title_text=”1″ url=”https:\/\/www.corriere.it\/salute\/sportello_cancro\/22_gennaio_31\/nuova-scoperta-lotta-cancro-serve-anche-dna-spazzatura-fdfec446-8061-11ec-bcde-80a2791c4316.shtml?refresh_ce” url_new_window=”on” _builder_version=”4.24.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_image src=”https:\/\/www.utopiasis.it\/wp-content\/uploads\/2024\/03\/4.png” title_text=”4″ url=”https:\/\/www.ansa.it\/canale_scienza_tecnica\/notizie\/biotech\/2022\/01\/18\/tumori-interruttori-di-rna-risvegliano-%20le-difese-immunitarie_f842c69c-046e-44c1-b6d3-f56d6be6f15f.html” url_new_window=”on” _builder_version=”4.24.2″ _module_preset=”default” custom_margin=”30px||||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_image src=”https:\/\/www.utopiasis.it\/wp-content\/uploads\/2024\/03\/7.png” title_text=”7″ url=”https:\/\/www.milanofinanza.it\/news\/ricerca-%20mfdj?testo=Utopia%20SIS%20&chkTitolo=False&datadal=&dataal=&pag=1″ url_new_window=”on” _builder_version=”4.24.2″ _module_preset=”default” custom_margin=”30px||||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.24.2″ _module_preset=”default” background_color=”gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14″ custom_padding=”20px|20px|20px|20px|true|true” global_colors_info=”{%22gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14%22:%91%22background_color%22,%22background_color%22%93}”][et_pb_image src=”https:\/\/www.utopiasis.it\/wp-content\/uploads\/2024\/03\/2.png” title_text=”2″ url=”https:\/\/www.metropolitano.it\/dalla-ricerca-italiana-una-scoperta-che-puo-rivoluzionare-la-lot” url_new_window=”on” _builder_version=”4.24.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_image src=”https:\/\/www.utopiasis.it\/wp-content\/uploads\/2024\/03\/5.png” title_text=”5″ url=”https:\/\/gds.it\/speciali\/scienza-tecnica\/2022\/01\/18\/tumori-interruttori-di-rna-risvegliano-le-difese-immunitarie-c8db0dd4-6eda-4e95-ac76-e09c2143fce0\/” url_new_window=”on” _builder_version=”4.24.2″ _module_preset=”default” custom_margin=”30px||||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_image src=”https:\/\/www.utopiasis.it\/wp-content\/uploads\/2024\/03\/8.png” title_text=”8″ url=”https:\/\/startupitalia.eu\/182594-20220927-t-one-therapeutics-spin-off-dellingm-ha-chiuso-un-round-di-25-milioni-di-%20euro” url_new_window=”on” _builder_version=”4.24.2″ _module_preset=”default” custom_margin=”30px||||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.24.2″ _module_preset=”default” background_color=”gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14″ custom_padding=”20px|20px|20px|20px|true|true” global_colors_info=”{%22gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14%22:%91%22background_color%22,%22background_color%22%93}”][et_pb_image src=”https:\/\/www.utopiasis.it\/wp-content\/uploads\/2024\/03\/3.png” title_text=”3″ url=”https:\/\/www.sanita24.ilsole24ore.com\/art\/notizie-flash\/2022-01-18\/dna-spazzatura-e%CC%80-grado-attivare-risposta-immunitaria-linfociti-t-sentinelle-lotta-tumori-113239.php?uuid=AEvNri8&refresh_ce=1″ url_new_window=”on” _builder_version=”4.24.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_image src=”https:\/\/www.utopiasis.it\/wp-content\/uploads\/2024\/03\/6.png” title_text=”6″ url=”https:\/\/www.insalutenews.it\/in-salute\/lotta-ai-tumori-il-dna-spazzatura-e-in-grado-di-attivare-la-risposta-%20immunitaria-dei-linfociti-t\/” url_new_window=”on” _builder_version=”4.24.2″ _module_preset=”default” custom_margin=”30px||||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

T-One Therapeutics s.r.l.T-ONE THERAPEUTICS SRL: LINE1 TO FIGHT CANCERThe company is a spin-off of the National Institute of Molecular Genetics “Romeo and Enrica Invernizzi” (INGM). The central point of Professor Beatrice Bodega’s discovery, co-founder of T-One Therapeutics, is attributing for the first time a crucial function in regulating the activation of T lymphocytes to certain […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" admin_label=\"sezione blocco 1\" _builder_version=\"4.24.2\" _module_preset=\"default\" background_color=\"gcid-ac150a38-2027-4fd4-8963-25e8b6f6f839\" custom_margin=\"85px||||false|false\" custom_padding=\"0px||0px||false|false\" global_colors_info=\"{%22gcid-ac150a38-2027-4fd4-8963-25e8b6f6f839%22:%91%22background_color%22%93}\"][et_pb_row column_structure=\"1_2,1_2\" use_custom_gutter=\"on\" gutter_width=\"1\" make_equal=\"on\" _builder_version=\"4.24.2\" _module_preset=\"default\" width=\"100%\" max_width=\"100%\" custom_padding=\"0px||0px||false|false\" global_colors_info=\"{}\"][et_pb_column type=\"1_2\" _builder_version=\"4.24.2\" _module_preset=\"default\" background_enable_image=\"off\" background_video_mp4=\"https:\/\/www.utopiasis.it\/wp-content\/uploads\/2024\/03\/iStock-1317698020.mov\" global_colors_info=\"{}\"][et_pb_image src=\"https:\/\/www.utopiasis.it\/wp-content\/uploads\/2024\/03\/logo-home.png\" title_text=\"logo-home\" _builder_version=\"4.24.2\" _module_preset=\"default\" background_color=\"#FFFFFF\" custom_margin=\"25%|25%|25%|25%|false|false\" custom_padding=\"20px|20px|20px|20px|false|false\" global_colors_info=\"{}\"][\/et_pb_image][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.24.2\" _module_preset=\"default\" custom_padding=\"100px|60px|100px|60px|true|true\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.24.2\" _module_preset=\"default\" header_2_text_color=\"gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14\" header_2_font_size=\"30px\" custom_margin=\"||0px||false|false\" locked=\"off\" global_colors_info=\"{%22gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14%22:%91%22header_2_text_color%22%93}\"]\n

T-One Therapeutics s.r.l.<\/h2>\n[\/et_pb_text][et_pb_divider color=\"gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14\" _builder_version=\"4.24.2\" _module_preset=\"default\" custom_margin=\"||0px||false|false\" custom_padding=\"||||false|false\" locked=\"off\" global_colors_info=\"{%22gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14%22:%91%22color%22%93}\"][\/et_pb_divider][et_pb_text _builder_version=\"4.24.2\" _module_preset=\"default\" header_4_text_color=\"gcid-b7a20a05-ac47-46ee-846a-44540a53bb38\" header_4_line_height=\"1.4em\" global_colors_info=\"{%22gcid-b7a20a05-ac47-46ee-846a-44540a53bb38%22:%91%22header_4_text_color%22%93}\"]\n

T-ONE THERAPEUTICS SRL: LINE1 PER COMBATTARE IL CANCRO<\/h4>\n[\/et_pb_text][et_pb_text _builder_version=\"4.24.2\" _module_preset=\"default\" text_text_color=\"#000000\" text_font_size=\"17px\" text_line_height=\"1.8em\" text_orientation=\"justified\" global_colors_info=\"{}\"]\n\nLa societ\u00e0 \u00e8 uno Spin-off dell\u2019Istituto Nazionale di Genetica Molecolare \u00abRomeo ed Enrica Invernizzi\u00bb (INGM).\n\nIl punto centrale della scoperta della professoressa Beatrice Bodega, co-fondatrice di\nT-One Therapeutics, \u00e8 aver attribuito per la prima volta una funzione cruciale nella regolazione dell\u2019attivazione dei linfociti T ad alcune sequenze del DNA umano (LINE1), sequenze ritenute per anni scarto genetico.\n\nI ricercatori di INGM hanno scoperto invece essere fondamentali nell\u2019inibire la funzionalit\u00e0 dei linfociti T, cellule del sistema immunitario che sono il bersaglio farmacologico principale per l\u2019immunoterapia dei tumori (terapia che negli ultimi 10 anni ha rivoluzionato il campo delle cure antitumorali).\n\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_6,1_6,1_6\" use_custom_gutter=\"on\" gutter_width=\"1\" make_equal=\"on\" _builder_version=\"4.24.2\" _module_preset=\"default\" width=\"100%\" max_width=\"100%\" custom_padding=\"0px||0px||false|false\" global_colors_info=\"{}\"][et_pb_column type=\"1_2\" _builder_version=\"4.24.2\" _module_preset=\"default\" custom_padding=\"100px|60px|100px|60px|true|true\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.24.2\" _module_preset=\"default\" text_text_color=\"#000000\" text_font_size=\"17px\" text_line_height=\"1.8em\" text_orientation=\"justified\" hover_enabled=\"0\" global_colors_info=\"{}\" sticky_enabled=\"0\"]\n\nPer degradare l'RNA di LINE1, la societ\u00e0 ha individuato delle molecole definite ASO.\n\nIl progetto si pone come obiettivo quello di individuare le molecole ASO che\npossano riattivare la risposta immunitaria dei Linfociti T \u00abesausti\u00bb all\u2019interno del microambiente tumorale e quindi combattere il tumore dall\u2019interno.\n\nUtopia ha investito ad Agosto 2022.\n\n[\/et_pb_text][et_pb_blurb title=\"www.tonetx.eu\" url=\"https:\/\/tonetx.eu\/\" url_new_window=\"on\" use_icon=\"on\" font_icon=\"I||divi||400\" icon_color=\"gcid-b7a20a05-ac47-46ee-846a-44540a53bb38\" icon_placement=\"left\" _builder_version=\"4.24.2\" _module_preset=\"default\" header_font=\"||||||||\" header_font_size=\"17px\" custom_margin=\"||||false|false\" custom_padding=\"30px||||false|false\" global_colors_info=\"{%22gcid-b7a20a05-ac47-46ee-846a-44540a53bb38%22:%91%22icon_color%22%93}\"][\/et_pb_blurb][\/et_pb_column][et_pb_column type=\"1_6\" _builder_version=\"4.24.2\" _module_preset=\"default\" background_color=\"gcid-e5dce679-c214-4f4d-9539-b4f3d3cd1a14\" custom_padding=\"20px|20px|20px|20px|true|true\" 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